Q. Does Coenzyme Q10 help reduce muscle problems and other statin-related side effects? And if so, should physicians give this information to patients when statins are prescribed?

A. Coenzyme Q10, a popular dietary supplement marketed as CoQ10 "to promote heart health," probably does not reduce statin-induced muscle problems .

In 1957, researchers at the University of Wisconsin discovered a helping molecule. muscle cells generate energy. Today, this molecule is known as coenzyme Q10.

In 1978, researchers, including Dr. Michael Brown and Joseph Goldstein, who won the Nobel Prize, noted that cholesterol and coenzyme Q10 were synthesized by the same biochemical pathway. As a result, statins not only lower cholesterol levels, they also deplete the body's coenzyme Q10 stores.

This discovery sparked a renewed interest in coenzyme Q10. Was his exhaustion the cause of muscular pain induced by statins? If so, could restoring the normal level of coenzyme Q10 with supplements address these issues? This theory has attracted many supporters, including Dr. Brown, who in 1989 filed a patent on coenzyme Q10 as a treatment for statin-induced muscle problems.

In the following years, coenzyme Q10 has been the subject of extensive studies as a treatment of statin-induced muscle problems. But studies have yielded contradictory results.

In 2015, the meta-analysis group of lipids and blood pressure combined data from six randomized controlled trials of coenzyme Q10 in the treatment of statin-induced muscle problems. The meta-analysis of 302 patients concluded that coenzyme Q10 was not beneficial. A subsequent randomized controlled trial of coenzyme Q10 in 41 patients with statin-induced muscle problems led to the same conclusion.

also found it ineffective.

Some correctly argue that studies on coenzyme Q10 were not large enough, or were not long enough, or used various preparations and doses of coenzyme Q10. Nevertheless, given the preponderance of evidence, there is no evidence that coenzyme Q10 helps prevent statin-induced muscle problems.

Like all dietary supplements, coenzyme Q10 is not regulated as a drug by the Food and Drug Administration. therefore, there may be significant differences between the products of different manufacturers. Side effects can also occur, including insomnia and stomach upset, which can interact with medications such as blood thinners, insulin, and certain chemotherapies. If you are taking coenzyme Q10, ask your doctor for advice.

Do you have a health question? Request well